4^thInternational Conference on Drug Discovery, Designing Chemistry and Pharmaceutical Analysis June 27-28, 2018 Vancouver, British Columbia, Canada

The modern drug discovery process is an overview to the development of new drugs. Now a days new biological targets, methodologies and advanced computing have enhanced modern drug discovery and have given medicinal chemistry a more thoughtful skill set and toolkit to hold the nuances  of disease pathophysiology. The medicinal chemistry related methodologies and a methodology in drug discovery improves the efficiency   in drug discovery and lessening attrition. In drug designing, Structure-based drug design, and fragment –based drug design, natural product-based drug design, diversity-based drug design, and chemo genomics are applied.

Natural products (secondary metabolites) have been more successful source of potential drug leads. Natural products still play a major role as starting material for drug discovery. There are several sources for natural products for drug discovery like plant sources, microbial sources, and marine sources. Natural products are very large in numbers with an excellent chemical diversity. Natural products discovery can be approached by using Cell-Based assays, Biochemical assays and newer drug discovery. Natural products have played a key role in Pharma research, as many medicines are either natural products or derivatives.

The chief impartial of pre-clinical studies is to define the safe dose for first-in-man study and assess a product's safety profile.  Pre-clinical development also recognized as pre-clinical studies and non-clinical studies .In the drug development, preclinical development, is a phase study which prior to earlier clinical trials can begin, and during which important possibility, iterative testing and drug safety data is composed. Generally, only one in every 5,000 compounds that arrives drug discovery to the stage of pre-clinical development befits as an approved drug. These pre-clinical studies involve local toxicity studies such as acute, sub-acute, chronic toxicity studies and systemic toxicity studies such as genotoxicity and carcinogenicity studies.

Nanotechnology is a study of science and technology which targets to regulate matter at the atomic, molecular, and macromolecular level. New nanotechnologies could bring intense increases in the sensitivity of detection technology for research and diagnostic applications, improved imaging technologies, greater selectivity for drug delivery, and detailed insight into biological mechanisms and systems. Nano biosensors and Nano biochips are used to develop drug discovery and development. Nano scale assays can subsidize substantially to cost-saving in screening promotions. The practice of Nano scale delivery vehicles prominent to the discovery of optimally safe in talling to effective drug candidates, current and promising applications of Nano medicine include, drug delivery, in vitro diagnostics, in vivo imaging, therapy techniques, biomaterials, and tissue engineering .As recognition of the importance of this moving field, it is estimated that the global market of Nano scale applications in medical field might grow to $70 - $160 bn.

Drug design, frequently called as rational drug design, is the resourceful process of discovering new medications based happening the knowledge of a biological target. The saying "drug design" is to also known as ligand design. This molecule design will bind tightly to its target. While design techniques for prediction of binding affinity are practically successful but there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that  must be enhanced before a ligand can become a safe and efficacious drug. The normal cost of developing new drug molecules and the period taken to market them is high. Molecular Modelling methods also known as Computational methods. These techniques can be utilized to speed up drug discovery process for earning new drug molecules. Reliant on the context and the rigor, the subject is often stated to as ‘molecular graphics’, ‘molecular visualizations’, ‘computational chemistry’, or ‘computational quantum chemistry’.

Clinical trial generates data on safety and efficacy. Such consequent biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interferences, including new treatments such as novel vaccines, drugs, dietary supplements, and medical devices. These trials produce data on safety and efficacy. The regulatory affairs outsourcing market has been segmented into five major service sections .Those sections include regulatory affairs, clinical trial applications and product registrations, regulatory writing and publishing, regulatory consulting and legal representation and others. The market sections have been broadly scheduled on the source of their usefulness, efficacy, and generated revenue and geographic revenue. 

The market size and estimate in USD million for every service type for the period from 2010 -2020, considering 2013 as basic year. This report also delivers the compounded annual growth rate (CAGR %) for each market segment for the forecast period from 2014- 2020.

In discovery procedure comprises the initial stages of research, which are intended to recognize an investigational drug and perform primary tests in the lab. This first stage of the process takes   three to six years. By the end, investigators hope to identify a capable drug aspirant to further study in the lab and in animal models, and then in people. These developments offer great ability, but also add complexity to the R&D process. In order to ensure the safety and efficacy of personalized therapies that are used along with diagnostics, clinical trial protocols must be improved and increased.

Computational Molecular Biology is a comparatively new science, with enormous growth since few years. Computational Biology is planned to afford a unique and in effect venue for the rapid publication of monographs, textbooks, edited collections, reference works, and lecture notes of the maximum quality. It deals with the key issues concerning analysis of genomes, sequences and structures. Bioinformatics is both  parasol term for the body of biological studies that use computer programming as part of their methodology, as well as a reference to specific analysis "pipelines" that are frequently used, mostly in the field of genomics.

Nanotechnology is an evolving unparalleled technology. It has substantial use in the diagnosis and treatment of disease and is highly prospective towards to be used in foods, cosmetics and medical products. Nanoparticles assurance to increase in capability and complexity. They are used to enhance the pharmacokinetic and pharmacodynamics profiles of many drug molecules. Biodegradable nanoparticles are using in pharmaceutical formulations to release and transport the drug efficiently.

Molecular mechanics is most commonly used to estimate the strength of the intermolecular interaction between the small molecule and its biological target. It can also be used to provide semi-quantitative prediction of the binding affinity.  This method will be able to predict affinity before a compound is synthesized and hence only one compound needs to be synthesized. Computational methods have accelerated finding by decreasing the number of iterations required and must often provide novel structures.

Formulation studies involve developing a preparation of the drug which is both stable and acceptable to the patient. Formulation studies are important to do a lot of formulation studies in order to detect the point of incorporation. Formulation studies must focus on other factors like particle size, polymorphism, pH and solubility, in order to check whether these factors will effect on bioavailability of the drug or not.

 The drug must be combined with inactive ingredients by a method which ensures that the quantity of drug present is consistent in each dosage unit e.g. each tablet. The word formulation is often used in a way which includes dosage forms.

The introduction of biotechnology-derived pharmaceuticals for clinical use has frequently required for the application of unique approaches to evaluating their safety in preclinical studies. There is abundant assortment among these products, which comprise the gene and cellular therapies, monoclonal antibodies, human-derived recombinant regulatory proteins, blood products, and vaccines. There will be distinctive product issues for many of the biological therapies that may definite precise modifications to protocol design and may raise additional safety concerns. Clinical trials are observations which are finished in clinical research and are accompanied only after they have received health authority/ethics committee approval in the country where approval of the therapy is required. These authorities are liable for screening the risk/benefit ratio of the trial. Their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.

Pharmaceutical and biomedical analysis deals with the diversified features of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. It is obvious throughout healthcare, from diagnosis and analysis to treatment and recovery, and has entered the public integrity though the propagation of implantable medical devices, such as pacemakers and artificial hips, to more futuristic technologies such as stem cell engineering and the 3-D printing of biological organs.